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		<title>Sigflow: an automated and comprehensive pipeline for cancer genome mutational signature analysis &middot; ShixiangWang
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						<h1 class="post-title p-name">Sigflow: an automated and comprehensive pipeline for cancer genome mutational signature analysis</h1>
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					<h3>Shixiang Wang (PhD), Ziyu Tao, Huimin Li, Xue-Song Liu (PhD)</h3>
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          <h3>Abstract</h3>
          <blockquote>Mutational signatures reflect the accumulated effects of both exogenous and endogenous mutational processes acting on cancer cells. Mutational signature analysis has been becoming a routine procedure after somatic variant calling in cancer genome study. Here we present Sigflow pipeline, which provides an one-stop solution for de novo signature extraction, reference signature fitting, signature stability analysis, and etc. in different types of genome DNA alterations.
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